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1. Evidence-based practice vs. best practice
Evidence-based practice is a type of research that has undergone some specific scientific evaluation steps before advocating it to be used in the care of patients and any kind of practice. On the other hand, best practice is an agreement made from research and, after proper discussion, may or may not end up being used in practice since it doesn’t go through any scientific evaluation.
2. Efficacy of randomized controlled trials vs. meta-analysis vs. interrogative reviews
There is more efficacy in randomized controlled trials compared to a meta-analysis in that it provides the best and high quality of evidence. This is so because little bias is incurred. However, in a meta-analysis, the level of bias increases, making it less efficient.
The randomized controlled trial is a research design that finds the difference between two groups of participants, the control group or the experimental group, while meta-analysis uses a design that concentrates on previous research results to make a conclusion. Hence, meta-analysis relies on randomized controlled trials. 
The interrogative review entails the entire process of identifying, selecting, and synthesizing evidence from conducted research. Therefore, out of the three, interrogative review is the most efficient since it involves step by step analysis of the research conducted and thus reduces bias.
3. Mechanisms of support of evidence-based practice
¢ Encouragement of individuals, organizations, and teams to adopt and consistently implement evidence-based results from research finds in day to day practices.
¢ Incorporate teaching and learning of evidence-based practice in the field of medicines to raise professionals that are utilizing evidence-based practice and will thus support a chance in practice.
¢ Identifying mentors who have in-depth knowledge and skills concerning evidence-based practice and giving them the role to mentor and act as role models to individuals as well as organizations and thus motivating them to use EBP consistently
4. Challenges in implementing evidence-based practice
¢ Poor understanding of the meaning and evidence-based practice works and thus makes it challenging to incorporate it in practice
¢ Lack of adequate support from nurse leaders, and therefore those nurses interested are demotivated.
¢ A misconception that while doing things the ideal way and use of evidence-based practice consumes time.
¢ Working in an organization where its culture, as well as its policy, allows one to practice without the need to apply EBP.
References
Bolunmez, B., & Dalal, R. S. (2016). Evidence-Based Strategies to Improve Workplace Decisions: Small Steps, Big Effects. Alexandria, VA: Society for Human Resources Management.